| Item Type | Name |
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Concept
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Toxin-Antitoxin Systems
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Concept
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Amino Acid Sequence
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Concept
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Binding Sites
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Concept
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Drug Screening Assays, Antitumor
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Concept
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Nucleic Acid Conformation
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Concept
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Microbial Sensitivity Tests
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Concept
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Molecular Sequence Data
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Concept
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Molecular Structure
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Concept
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Signal Transduction
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Concept
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Staphylococcal Infections
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Concept
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Staphylococcus
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Concept
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Staphylococcus aureus
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Concept
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Stereoisomerism
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Concept
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Structure-Activity Relationship
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Concept
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Substrate Specificity
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Concept
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Protein Structure, Secondary
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Concept
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Protein Structure, Tertiary
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Concept
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Sequence Alignment
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Concept
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Genome, Bacterial
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Concept
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Genome, Archaeal
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Concept
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Protein Structure, Quaternary
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Concept
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Space Flight
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Concept
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United States
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Concept
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Chemistry Techniques, Synthetic
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Concept
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Structural Homology, Protein
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Concept
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High-Throughput Screening Assays
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Concept
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National Institute of Allergy and Infectious Diseases (U.S.)
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Concept
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Molecular Docking Simulation
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Academic Article
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Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.
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Academic Article
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Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis.
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Academic Article
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The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking.
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Academic Article
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Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95.
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Academic Article
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Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
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Academic Article
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Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets.
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Academic Article
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Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines.
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Academic Article
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Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis.
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Academic Article
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Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductase.
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Academic Article
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Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis.
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Academic Article
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Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex.
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Academic Article
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Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase.
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Academic Article
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Identifying a Molecular Mechanism That Imparts Species-Specific Toxicity to YoeB Toxins.
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Academic Article
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A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly.
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Academic Article
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Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase.
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Academic Article
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Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics.
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Academic Article
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Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics.
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Academic Article
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Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways.
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Academic Article
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The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics.
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Academic Article
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Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems.
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Academic Article
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Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody.
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Academic Article
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Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1.
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Academic Article
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In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions).
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Academic Article
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Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle.
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Academic Article
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A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly.
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Academic Article
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High-throughput screening of a diversity collection using biodefense category A and B priority pathogens.
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Academic Article
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Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.
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Academic Article
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Bacterial Growth Mindset: Structural Plasticity in Defense Systems.
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Academic Article
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A YoeB toxin cleaves both RNA and DNA.
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Academic Article
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Molecular Basis for the Substrate Promiscuity of Isopentenyl Phosphate Kinase from Candidatus methanomethylophilus alvus.
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Academic Article
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ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics.
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